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  • Title: [Experimental study on antagonism of ginkgolides against effect of platelet-activating factor on lung strip of guinea pigs].
    Author: Dong JC, Li M, Wu GT.
    Journal: Zhongguo Zhong Xi Yi Jie He Za Zhi; 1997 Aug; 17(8):481-3, 502. PubMed ID: 10322836.
    Abstract:
    OBJECTIVE: To investigate the action of ginkgolides antagonizing the contraction of guinea pigs' lung strip induced by the mixture of platelet-activating factor (PAF) and platelets and its effect of preventing the PAF caused damage of beta-adrenergic receptors. METHODS: The contraction of guinea pigs' isolated lung strip was measured. RESULTS: The mixture of PAF and platelet could produce a serious contraction of lung strip, the IC50 reached 4.69 x 10(-7) mol/L, while the contraction induced by PAF alone was relatively mild, its IC50 only 6.66 x 10(-4) mol/L, the difference between them was significant (P < 0.05). When the platelets were preincubated with ginkgolides for 10 minutes in Tris-Tyrode's buffered saline, the effects of PAF and platelets mixture were significantly inhibited (P < 0.05). Exposure of guinea pigs' lung strip to PAF in vitro resulted in a loss of beta-adrenergic receptors and weakened its respones to isoproterenol, a receptor activating factor, the EC50 would be increased from 1.38 x 10(-6) mol/L to 6.25 x 10(-6) mol/L, P < 0.05. This effect of PAF could also be inhibited by ginkgolides (P < 0.05). CONCLUSION: Ginkgolides is a promising PAF antagonist, and might be used in treating bronchial asthma.
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