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  • Title: Mannitol and frusemide in the treatment of diuretic resistant oedema in nephrotic syndrome.
    Author: Lewis MA, Awan A.
    Journal: Arch Dis Child; 1999 Feb; 80(2):184-5. PubMed ID: 10325739.
    Abstract:
    Three children (two girls aged 7 and 9 years, and one boy aged 4 years) with diuretic resistant oedema in steroid resistant nephrotic syndrome were treated with a combination of intravenous mannitol and frusemide. All three responded with loss of oedema of 10% to 30% of body weight over one week. There were no complications of hypertension or hypovolaemia. Mannitol-frusemide combination is a safe, inexpensive, and effective treatment for diuretic resistant oedema. Its use in other conditions and in developing countries (where the availability and purity of 20% albumin is limited) needs to be explored.
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