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  • Title: Electrophysiological findings in Stargardt's-fundus flavimaculatus disease.
    Author: Stavrou P, Good PA, Misson GP, Kritzinger EE.
    Journal: Eye (Lond); 1998; 12 ( Pt 6)():953-8. PubMed ID: 10325994.
    Abstract:
    PURPOSE: To determine the incidence of electrophysiological abnormalities in patients with Stargardt's-fundus flavimaculatus (STGD/FFM) disease. METHODS: A retrospective review was carried out of the hospital records of 46 patients who had undergone a scotopic, single flash photopic and 30 Hz electroretinogram (ERG), pattern ERG (PERG) and electro-oculogram (EOG). RESULTS: Patients were classified in two groups: those with flecks (n = 26) and those without flecks (n = 20). The incidence of abnormalities (amplitude and/or latency) for the two groups was: PERG, 90% and 98%; 30 Hz ERG, 55.8% and 50%; scotopic ERG, 38.5% and 27.5%; and single flash photopic ERG, 26% and 16%, respectively. EOG abnormalities occurred significantly more frequently in the group with flecks compared with the group without flecks: 69% and 42.5% respectively (p < 0.025). Furthermore, in the group with flecks the group mean scotopic ERG b-wave, 30 Hz ERG b-wave and PERG (P50) amplitude were significantly lower than in the group without flecks (p < 0.01). CONCLUSIONS: The most consistent electrophysiological abnormality in STGD/ FFM is the reduction of the PERG. However, EOG, 30 Hz ERG, scotopic and photopic ERG abnormalities can also frequently occur. ERG and EOG abnormalities occur more often in the presence of flecks.
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