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  • Title: [Thymoma and hypogammaglobulinemia. Good's syndrome: apropos of a case and review of the literature].
    Author: Granel B, Gayet S, Christides C, Serratrice J, Rey J, Disdier P, Weiller PJ.
    Journal: Rev Med Interne; 1999 Apr; 20(4):347-9. PubMed ID: 10327479.
    Abstract:
    INTRODUCTION: Good's syndrome is defined as the association of thymoma, hypogammaglobulinemia, and repetitive bronchopulmonary infections. We report one case and review the clinical and immunological features of this syndrome. EXEGESIS: We describe the case of a 67-year-old man who presented with both severe bronchopulmonary infection resistant to antibiotherapy and thymoma. Definite diagnosis was based on the existence of hypogammaglobulinemia. Treatment with intravenous immunoglobulins led to positive outcome. CONCLUSION: Good's syndrome occurs in only 5% of parathymic diseases. To prevent further bronchial tube destruction and pulmonary surgery, it must be diagnosed and treated early.
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