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  • Title: The effect of daily norethisterone (0.35 mg) on cervical mucus and on urinary LH, pregnanediol and oestrogen levels.
    Author: Elstein M, Briston PG, Hewitt KJ, Kirk D, Miller H.
    Journal: Br J Obstet Gynaecol; 1976 Feb; 83(2):165-8. PubMed ID: 1032819.
    Abstract:
    The effect of 0.35 mg of norethisterone daily on cervical mucus and on urinary LH, pregnanediol and oestrogen levels was studied during two treatment cycles in five subjects who had been observed during a control cycle. Variable changes in hormone excretion patterns were found and are discussed. The effects of .35 mg of norethisterone/day on cervical mucus and on urinary luteinizing hormone (LH), pregnanediol, and estrogen levels were studied during 2 treatment cycles in 5 healthy women who had been observed during a control cycle. LH was measured by radioimmunoassay, total estrogens by a semiautomatic rapid method, and pregnanediol by a gas chromatographic method. There was some effect on the LH excretion patte rn in all the treatment cycles. Pregnanediol levels suggested ovulation in 3 cycles. In all 3 of these cycles the LH peak was lower and not as pronounced as in the respective control cycles. A patient with some initial suppression of LH and estrogens became pregnant during the trial. Cervical mucus was scanty, thick, opaque, and impenetrable to sperm throughout treatment. Spotting occurred in 4 of the treatment cycles, 2 of which were ovulatory. 3 possible ways in which norethisterone might exert its contraceptive effect are listed.
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