These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Necrotizing encephalopathy and macrocephaly with mitochondrial complex I deficiency.
    Author: Feillet F, Mousson B, Grignon Y, Leonard JV, Vidailhet M.
    Journal: Pediatr Neurol; 1999 Apr; 20(4):305-8. PubMed ID: 10328281.
    Abstract:
    A neonate presented in the first weeks after birth with vomiting. He was unresponsive, with hypotonia, macrocephaly, and lactic acidosis. The cranial computed tomographic scan revealed a hypodense brain, with increased brain volume and extensive cerebral edema. He died at 6 weeks of age; postmortem examination revealed necrotizing encephalopathy with marked brain edema, spongiosis, thalamic necrosis, and basal ganglia calcifications. Enzyme studies of the mitochondrial respiratory chain revealed complex I deficiency in both muscle and liver.
    [Abstract] [Full Text] [Related] [New Search]