These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: An isotope dilution model for partitioning leucine uptake by the liver of the lactating dairy cow.
    Author: France J, Hanigan MD, Reynolds CK, Dijkstra J, Crompton LA, Maas JA, Bequette BJ, Metcalf JA, Lobley GE, MacRae JC, Beever DE.
    Journal: J Theor Biol; 1999 May 07; 198(1):121-33. PubMed ID: 10329119.
    Abstract:
    An isotope dilution model for partitioning leucine uptake by the liver of the lactating dairy cow is constructed and solved in the steady state. If assumptions ae made, model solution permits calculation of the rate of leucine uptake from portal and hepatic arterial blood supply, leucine export into the hepatic vein, leucine oxidation and transamination, and synthesis and degradation of hepatic constitutive and export proteins. The model requires the measurement of plasma flow rate through the liver in combination with leucine concentrations and plateau isotopic enrichments in arterial, portal and hepatic plasma during a constant infusion of [1-13C]leucine tracer. The model can be applied to other amino acids with similar metabolic fates and will provide a means for assessing the impact of hepatic metabolism on amino acid availability to peripheral tissues. This is of particular importance when considering the dairy cow and the requirements of the mammary gland for milk protein synthesis.
    [Abstract] [Full Text] [Related] [New Search]