These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Frequency of the fragile X syndrome in Chinese mentally retarded populations is similar to that in Caucasians.
    Author: Zhong N, Ju W, Xu W, Ye L, Shen Y, Wu G, Chen SH, Jin R, Hu XF, Yang A, Liu X, Poon P, Pang C, Zheng Y, Song L, Zhao P, Fu B, Gu H, Brown WT.
    Journal: Am J Med Genet; 1999 May 28; 84(3):191-4. PubMed ID: 10331588.
    Abstract:
    Fragile X syndrome is recognized as the most common inherited cause of mental retardation in western countries. The prevalence of the fragile X syndrome in Asian populations is uncertain. We report a multi-institutional collaborative study of molecular screening for the fragile X syndrome from 1,127 Chinese mentally retarded (MR) individuals. We found that 2.8% of the Chinese MR population screened by DNA analysis had the fragile X full mutation. Our screening indicated that the fragile X syndrome prevalence was very close to that of Caucasian subjects. In addition, we found that 62.5% of fragile X chromosomes had a single haplotype for DXS548-FRAXAC1 (21-18 repeats) which was present in only 9.7% of controls. This unique distribution of microsatellite markers flanking the FMR1 CGG repeats suggests that the fragile X syndrome in Chinese populations, as in the Caucasian, may also be derived from founder chromosomes.
    [Abstract] [Full Text] [Related] [New Search]