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  • Title: Orbital chondrosarcoma developing in a patient with Paget disease.
    Author: Mooy CM, Naus NC, de Klein A, van den Bosch WA, Paridaens DA.
    Journal: Am J Ophthalmol; 1999 May; 127(5):619-21. PubMed ID: 10334366.
    Abstract:
    PURPOSE: To describe the radiologic, histopathologic, and cytogenetic features of an orbital chondrosarcoma developing in a patient with Paget disease. METHODS: A 64-year-old woman presented with rapidly progressive proptosis of her right eye. Computed tomographic scans, histopathologic examination, and cytogenetic analysis were performed. RESULTS: Computed tomographic scans disclosed osseous changes of the temporal and frontal bones, with areas of high density consistent with Paget disease. A soft-tissue tumor in the right lateral orbital wall was consistent with Paget sarcoma. On histology, a chondrosarcoma was diagnosed, which was confirmed by fluorescent in situ hybridization. CONCLUSION: This is a unique case of orbital chondrosarcoma developing in a patient with Paget disease.
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