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  • Title: A retrospective follow-up study on intracytoplasmic sperm injection.
    Author: Van Golde R, Boada M, Veiga A, Evers J, Geraedts J, Barri P.
    Journal: J Assist Reprod Genet; 1999 May; 16(5):227-32. PubMed ID: 10335467.
    Abstract:
    PURPOSE: Genetic aspects of male subfertility and the novelty of intracytoplasmic sperm injection (ICSI) as a new technique can influence the development of zygotes and children born after ICSI. Therefore, we evaluated the outcome of ICSI compared to in vitro fertilization (IVF). METHODS: Data from medical records of 233 total pregnancies and the follow-up of 132 children born after IVF and 120 after ICSI were retrospectively analyzed. RESULTS: No differences were found between ICSI and IVF for early embryonic development and obstetric outcome. In both groups the rate of women undergoing prenatal chromosomal diagnosis was low, 30.0%. The congenital malformation rate was 3.0% after IVF and 1.7% after ICSI, which was not significantly different. Follow-up on development of children born after IVF and ICSI also showed no significant differences. CONCLUSIONS: Our results indicate that at this moment ICSI is a safe procedure. However, a consistent prospective follow-up is still mandatory to exclude possible risks.
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