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  • Title: The mouse cpp32 mRNA transcript is early up-regulated in axotomized motoneurons following facial nerve transection.
    Author: de Bilbao F, Guarin E, Nef P, Dubois-Dauphin M.
    Journal: Neurosci Lett; 1999 Apr 30; 266(1):65-8. PubMed ID: 10336185.
    Abstract:
    In adult mice, axotomy of facial motoneurons induces apoptotic cell death. Cpp32, Bax and Bcl-xl are regulators of this type of cell death in the central nervous system. Using in situ hybridization, we have studied the kinetics of expression of cpp32, bax and bcl-xl mRNAs after a fatal lesion of the facial nerve in wild-type and Bcl-2 transgenic mice, where cell death is known to be prevented. In both strains of mice, cpp32 mRNA was up-regulated by 12 h following axotomy whereas changes in bax mRNA expression occurred later (from 3 days). These results provide information on the timing of molecular processes involved in cell death and could be helpful in determining a critical period during which they may be blocked.
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