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  • Title: Corticotropin releasing factor in the brain of the gymnotiform fish, Apteronotus leptorhynchus: immunohistochemical studies combined with neuronal tract tracing.
    Author: Zupanc GK, Horschke I, Lovejoy DA.
    Journal: Gen Comp Endocrinol; 1999 Jun; 114(3):349-64. PubMed ID: 10336823.
    Abstract:
    The expression of corticotropin-releasing factor (CRF) has been studied by immunohistochemistry in the brain of the gymnotiform fish, Apteronotus leptorhynchus. Labeled somata were found exclusively in the posterior subdivision of the nucleus preopticus periventricularis and in the hypothalamus anterioris, where these cells form a continuous cluster of neurons. Combination of anti-peptide immunohistochemistry with an in vitro tract-tracing technique confirmed that at least some of these neurons project to the pituitary. Additional terminal fields were present in the following areas of the telencephalon and the diencephalon: ventral subdivision of the ventral telencephalon, supracommissural subdivision of the ventral telencephalon, anterior subdivision of the nucleus preopticus periventricularis, inferior subdivision of the nucleus recessus lateralis, central posterior/prepacemaker nucleus, hypothalamus dorsalis and lateralis, medial subdivision 2 of the nucleus recessus lateralis, and in the region between the dorsal edge of the nucleus tuberis anterior on the one side and both the glomerular nucleus and the central nucleus of the inferior lobe on the other side. It is likely that the projection of CRF-expressing neurons of the posterior subdivision of the nucleus preopticus periventricularis/hypothalamus anterioris to the pituitary provides, similarly as in other fishes, the neural substrate for the activation of the hypothalamo-pituitary adrenal axis through CRF. In addition to this function, CRF may be involved in the regulation of several other processes, including neural control of communicatory behavior exerted by neurons of the central posterior/prepacemaker nucleus.
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