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  • Title: Betaxolol versus carvedilol in chronic heart failure (BETACAR study). Rationale and design.
    Author: Böhler S, Saubadu S, Scheldewaert R, Figulla HR.
    Journal: Arzneimittelforschung; 1999 Apr; 49(4):311-7. PubMed ID: 10337449.
    Abstract:
    The use of beta-blockers in heart failure for a long time was regarded as contra-indicated because of their negative inotropic effects. Nevertheless, there is growing evidence that beta-blockers slow down the progression of left ventricular dilatation that characterizes heart failure. In addition changes in left ventricular ejection fraction after several months of beta-blocker treatment appears to have predictive value for survival. This beneficial effect of beta-blockade in chronic heart failure needs to be assessed further. The presumed benefit of beta-blockade with betaxolol (CAS 63659-18-7), a highly selective beta-blocker with long duration of action in chronic heart failure (CHF) will be assessed in BETACAR, a comparative study versus carvedilol (CAS 72956-09-3). The design of this study is provided in this article.
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