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  • Title: Cross-sensitivity and the anticonvulsant hypersensitivity syndrome.
    Author: Moss DM, Rudis M, Henderson SO.
    Journal: J Emerg Med; 1999; 17(3):503-6. PubMed ID: 10338246.
    Abstract:
    The anticonvulsant hypersensitivity syndrome is a rare complication that occurs with the use of antiepileptic medications. Although phenytoin is the most common culprit, carbamazepine and phenobarbital are known to cause a similar reaction. A familial occurrence has been reported. We present a case of the anticonvulsant hypersensitivity syndrome to emphasize the importance of recognizing the multiple clinical components of the syndrome and to raise awareness of the cross-sensitivity among anticonvulsants metabolized via arene oxide metabolites.
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