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  • Title: Fluorine-19 solid-state NMR magic-angle-turning experiments using multiple-pulse homonuclear decoupling.
    Author: Hughes E, Brouwer EB, Harris RK.
    Journal: J Magn Reson; 1999 Jun; 138(2):256-67. PubMed ID: 10341129.
    Abstract:
    For compounds giving "crowded" 1-dimensional magic-angle-spinning spectra, information about the local atomic environment in the form of the chemical shift anisotropy (CSA) is sacrificed for high resolution of the less informative isotropic chemical shift. Magic-angle-turning (MAT) NMR pulse sequences preserve the CSA information by correlating it to the isotropic chemical shift in a 2-dimensional experiment. For low natural abundance nuclei such as 13C and 15N and under 1H heteronuclear dipolar decoupling conditions, the dominant NMR interaction is the chemical shift. For abundant nuclei such as 1H, 19F, and 31P, the homonuclear dipolar interaction becomes a significant contribution to the observed linewidth in both F1 and F2 dimensions. We incorporate MREV8 homonuclear multiple-pulse decoupling sequences into the MAT experiment to give a multiple-pulse MAT (MP-MAT) experiment in which the homonuclear dipolar interaction is suppressed while maintaining the chemical shift information. Extensive use of computer simulation using GAMMA has guided the pulse sequence development. In particular, we show how the MREV8 pulses can be incorporated into a quadrature-detected sequence such as MAT. The MP-MAT technique is demonstrated for a model two-site system containing a mixture of silver trifluoroacetate and calcium difluoride. The resolution in the isotropic evolution dimension is improved by faster sample spinning, shorter MREV8 cycle times in the evolution dimension, and modifications of the MAT component of the pulse sequence. Copyright 1999 Academic Press.
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