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  • Title: [Renal tubular acidosis with severe hypokalemic tetraparesis after ibuprofen intake].
    Author: Gaul C, Heckmann JG, Druschky A, Schöcklmann H, Neundörfer B, Erbguth F.
    Journal: Dtsch Med Wochenschr; 1999 Apr 23; 124(16):483-6. PubMed ID: 10341751.
    Abstract:
    HISTORY: A 72-year-old woman was admitted because of severe acute tetraparesis, more marked proximally. For six months she had been taking ibuprofen, up to 4800 mg daily, for a painful ulcer of the lower leg. INVESTIGATIONS: Biochemical tests revealed marked hypokalaemia (serum potassium 1.4 mmol/l) with a metabolic acidosis (pH 7.29). The ECG showed changes of hypokalaemia (ST-segment depression and U wave). TREATMENT AND COURSE: Within two days of administering potassium and bicarbonate the pareses completely regressed. Transitorily abnormal renal functions also rapidly normalized after ibuprofen had been discontinued. CONCLUSION: The biochemical findings suggest renal tubular acidosis, type 2, most likely caused by the excess intake of ibuprofen, a drug which can cause renal dysfunctions with life-threatening electrolyte abnormalities.
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