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  • Title: [Effect of truncal vagotomy on the occurence of gastric mucosal lesions induced by hemorrhagic shock in piglets (author's transl)].
    Author: Seufert RM, Hottenrott C, Büsing M, Gerstenbergk Lv.
    Journal: Res Exp Med (Berl); 1976 Dec 30; 169(2):133-43. PubMed ID: 1034317.
    Abstract:
    3 groups of total 37 mini-pigs have been bled to a mean aortic blood pressure of 40 mm Hg for three hours (Norton et al., 1972): Group I: hemorrhagic shock along (n = 15) Group II: right thoracotomy prior to shock without vagotomy (n = 4) Group III: right thoracotomy prior to shock with truncal vagotomy right above diaphragm (n = 15) 3 animals died during shock. All others showed severe mucosal hyperaemia and hemorrhage after shock, which intensified in animals without vagotomy during 8-24 hours. Gastric mucosal lesions of vagotomized animals did not differ to those of group I and II, when the animals were killed 4-8 hours after shock. However, there was a significant reduction of early changes after 12-24 hours, when compared to groups I and II. This study shows, that truncal vagotomy has no effect on the occurence of gastric mucosal lesions, which are induced by hemorrhagic shock in piglets, but prevents these from developing into severe bleeding peptic ulceration.
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