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  • Title: Scar formation after skin injury to the human foetus in utero or the premature neonate.
    Author: Morrison WA, Hurley JV, Ahmad TS, Webster HR.
    Journal: Br J Plast Surg; 1999 Jan; 52(1):6-11. PubMed ID: 10343583.
    Abstract:
    A macroscopically visible scar was present at birth in three infants with a history of injury during amniocentesis at 16-20 weeks' gestation. In several neonates born between 21 and 31 weeks' gestation, chemical injury to the skin caused by extravasation of calcium gluconate healed by formation of a large scar. In the infant born at 21 weeks, biopsy of the injured area showed infiltration by large numbers of neutrophils and macrophages. It appears that a very immature neonate can mount a prominent inflammatory reaction and that both a midtrimester foetus and a very immature neonate heal injuries to the skin by scar formation and not by scarless healing.
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