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  • Title: Splenectomy induced complete remission in a patient with multicentric Castleman's disease and autoimmune hemolytic anemia.
    Author: Lerza R, Castello G, Truini M, Ballarino P, Tredici S, Cavallini D, Pannacciulli I.
    Journal: Ann Hematol; 1999 Apr; 78(4):193-6. PubMed ID: 10348152.
    Abstract:
    Castleman's disease (CD) is a rare disorder of the lymphoid tissue in which the clinical manifestations often mimic a malignant lymphoma. Despite the absence of monoclonality of the lymphoid proliferation, the multicentric variant of the disease (MCD) is characterized by severe symptoms and poor prognosis. Etiologic, pathogenetic, and therapeutic aspects of MCD are still uncertain. We report the case of a 57-year-old patient affected by MCD complicated by severe immunohemolytic anemia. Whereas the clinical and laboratory response to steroids and chemotherapeutic agents was only partial, splenectomy induced a complete remission of hemolysis and disappearance of the constitutional symptoms and of all generalized lymphadenopathies.
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