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  • Title: In vitro activities of pyronaridine, alone and in combination with other antimalarial drugs, against Plasmodium falciparum.
    Author: Ringwald P, Eboumbou EC, Bickii J, Basco LK.
    Journal: Antimicrob Agents Chemother; 1999 Jun; 43(6):1525-7. PubMed ID: 10348789.
    Abstract:
    The in vitro activities of pyronaridine, alone and in combination with established antimalarial drugs, were assessed by isotopic microtest. Pyronaridine was highly active against all Cameroonian isolates. A positive correlation was observed between the response to pyronaridine and that to chloroquine. Drug combination studies showed synergy between pyronaridine and primaquine, additive effects with 4-aminoquinolines, and weak antagonism with dihydroartemisinin, antifolates, or amino alcohols.
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