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  • Title: Dopaminergic modulation of pallidal preproenkephalin mRNA.
    Author: Schuller JJ, Billings LM, Marshall JF.
    Journal: Brain Res Mol Brain Res; 1999 May 21; 69(1):149-53. PubMed ID: 10350647.
    Abstract:
    The present study examines dopaminergic regulation of neuropeptide gene expression within a relatively poorly characterized population of cells, the preproenkephalin (PPE) mRNA containing neurons of the globus pallidus (GP). Rats that received 6-hydroxydopamine (6-OHDA) lesions or repeated D1 or D2 antagonist administration were compared to control animals. One month after 6-OHDA lesions, PPE mRNA was elevated in the GP ipsilateral to the lesion, with a smaller elevation also being observed in the contralateral GP. Repeated administration of eticlopride, but not SCH 23390, also resulted in elevated PPE mRNA expression in the GP. These data reveal a novel effect of decreased dopamine transmission on the GP, and draw attention to this subpopulation of pallidal neurons.
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