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  • Title: Intravenous immunoglobulin and anti-D in idiopathic thrombocytopenic purpura (ITP): mechanisms of action.
    Author: Lazarus AH, Freedman J, Semple JW.
    Journal: Transfus Sci; 1998 Sep; 19(3):289-94. PubMed ID: 10351141.
    Abstract:
    Infusion of large amounts of intravenous immunoglobulin (IVIG) or anti-D can reverse the low platelet count in patients with ITP within hours of the initiation of treatment. In some cases, the effects of IVIG appear to far outlast several half-lives of the product. Several mechanisms have been proposed to explain these rapid and long term effects and these will be discussed in this review.
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