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Title: Transcontinental spread of multidrug-resistant Mycobacterium bovis. Author: Long R, Nobert E, Chomyc S, van Embden J, McNamee C, Duran RR, Talbot J, Fanning A. Journal: Am J Respir Crit Care Med; 1999 Jun; 159(6):2014-7. PubMed ID: 10351954. Abstract: Globally, the proportion of all cases of tuberculosis (TB) caused by drug-resistant strains is increasing. We report the case of a Canadian citizen who acquired a highly drug-resistant strain of Mycobacterium bovis while visiting a relative with AIDS-related tuberculosis in Spain. The origin of the strain was traced using spoligotyping, a polymerase chain reaction (PCR)-based fingerprint technology, and the European DNA database. The level of primary drug resistance-all five first-line drugs and 19 of 21 second-line drugs-in this case was unprecedented in Canada. Isolation of this strain from a Canadian citizen represents the first report of its appearance in this hemisphere. The infection was contained and combined medical-surgical treatment delivered.[Abstract] [Full Text] [Related] [New Search]