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  • Title: Exfoliative cytology in screening for malignant and premalignant lesions in the buccal mucosa.
    Author: Ramaesh T, Ratnatunga N, Mendis BR, Rajapaksa S.
    Journal: Ceylon Med J; 1998 Dec; 43(4):206-9. PubMed ID: 10355174.
    Abstract:
    OBJECTIVE: To test the efficacy of exfoliative cytology in the detection of oral premalignant and malignant lesions. DESIGN: Cytological diagnosis of lesions of the buccal mucosa assessed using histopathological diagnosis of the same lesions as the gold standard. SUBJECTS: Patients with buccal lesions clinically diagnosed as leukoplakia (n = 91) and squamous cell carcinoma (SCC, n = 59), and healthy subjects (n = 40) in whom buccal mucosa appeared clinically normal. SETTING: Oral and Maxillo-facial Unit, General Hospital, Kandy and Department of Pathology, Faculty of Medicine, University of Peradeniya. RESULTS: A sensitivity of 77%, specificity of 100% and accuracy of 92% were obtained for leukoplakia. SCC gave a sensitivity of 94%, specificity of 100% and an accuracy of 95%. CONCLUSIONS: Oral exfoliative cytology is a useful method for detecting oral premalignant and malignant lesions. Anucleated squames in a smear is non-diagnostic.
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