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  • Title: Probes of beta-galactosidase structure with antibodies. Reaction of anti-peptide antibodies against native enzyme.
    Author: Celada F, Fowler AV, Zabin I.
    Journal: Biochemistry; 1978 Nov 28; 17(24):5156-60. PubMed ID: 103569.
    Abstract:
    Antibodies were prepared against 18 tryptic and cyanogen bromide peptides from beta-galactosidase ranging in size from 15 to 96 amino acid residues representing more than 80% of the polypeptide chain. They were tested for binding capacity and affinity toward their homologous antigens and toward the whole native protein. Nine antisera bound to beta-galactosidase; these had been raised against certain peptides from the central and carboxyl-terminal regions of the poly-peptide chain. Based on these results a preliminary model of the three-dimensional structure of the folded protein is suggested.
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