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  • Title: [Cardio-hemodynamic effects of domestic adrenergic beta-antagonist proxodolol in hypertension in patients with pacemaker].
    Author: Iskenderov BG, Tatarchenko IP, Shevyrev VA.
    Journal: Klin Med (Mosk); 1999; 77(4):29-31. PubMed ID: 10356914.
    Abstract:
    59 patients with mild and moderate essential hypertension have received a course treatment with beta-adrenoblocker proxodolol. The latter was studied for a hypotensive action and cardiohemodynamic effects as regards baseline type of circulation and pacing regimen. Proxodolol hypotensive action in hyperkinetic circulation is attributed primarily to a fall in the ejection (beta-adrenoblock), in hypo- and eukinetic circulation type--to reduction in cardiac postload (alpha-adrenoblock). In isolated ventricular stimulation proxodolol cardiodepressive effect was more pronounced than in atrial stimulation. An overall hypotensive effect of proxodolol in mild arterial hypertension made up 77.2%, in moderate--66.5%.
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