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  • Title: [Impact of arterial hypertension on the heart].
    Author: Herpin D.
    Journal: Rev Prat; 1999 Mar 01; 49(5):491-4. PubMed ID: 10358398.
    Abstract:
    Heart involvement in systemic hypertension more often consists of a concentric left ventricular hypertrophy, rather than of an eccentric hypertrophy or of a left ventricular remodeling. These morphological abnormalities are seen in 25% of the hypertensive patients and can easily be diagnosed by using echocardiography. Underlying mechanisms of hypertensive left ventricular hypertrophy are of 2 types: mechanical, mainly leading to myocyte hypertrophy; neuro-hormonal, mainly resulting in a fibroblastic proliferation. Associated with hypertensive left ventricular hypertrophy is a poor spontaneous prognosis: arrhythmias, myocardial ischaemia (with or without narrowings of epicardial arteries), abnormalities in left ventricular diastolic function. Anti-hypertensive drugs result in an additional benefit, in terms of cardiovascular morbidity and mortality, when both a reduction in blood pressure and a regression of left ventricular hypertrophy can be achieved.
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