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  • Title: Effect of Hibiscus rosa sinensis Linn. on oestrous cycle & reproductive organs in rats.
    Author: Kholkute SD, Chatterjee S, Udupa KN.
    Journal: Indian J Exp Biol; 1976 Nov; 14(6):703-4. PubMed ID: 1035904.
    Abstract:
    The effect of Hibiscus rosa sinensis Linn. on the estrous cycle and reproductive organs was studied in female albino rats. Depending on the dose and duration of treatment, the benzene extract of the flowers disrupted the estrous cycle. Treatment for 30 days resulted in a significant (p less than .05) reduction in the weight of the ovaries, uterus, and pituitary gland. Ovarian follicular atresia and uterine atrophy were observed. Treatment resulted in degranulated gonadotrophs in the pituitary, with the extent of damage being dose-dependent.
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