These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Screening for mitochondrial 1555(G) mutation in patients with aminoglycoside antibiotic-induced deafness].
    Author: Yuan H, Jiang S, Yang W, Guo W, Cao J, Dai P.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 1999 Jun; 16(3):141-4. PubMed ID: 10359861.
    Abstract:
    OBJECTIVE: To identify the incidence of the 1555(G) mutation in pedigrees and sporadic patients with aminoglycoside antibiotic- induced deafness so as, to privide the theoretical evidence for establishing the method of diagnosis of this disease. METHODS: Blood samples were obtained from two pedigrees and seven sporadic patients with aminoglycoside antibiotic-induced deafness, and five mothers of the sporadic patients. DNA was extracted from the isolated leukocytes. The mitochondrial DNA fragments were amplified by PCR; 1555(G) mutation was detected by Alw26 I restriction endonuclease digestion. RESULTS: Fourteen individuals from two pedigrees carried homoplasmic 1555(G) mutation. Seven sporadic patients and the five mothers did not have 1555(G) mutation. CONCLUSION: The incidence of the 1555(G) mutation in pedigrees with aminoglycoside antibiotic-induced deafness is fairly high, while in sporadic patients is low. Screening for mitochondrial 1555(G) mutation is of potential value to clinical use.
    [Abstract] [Full Text] [Related] [New Search]