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  • Title: Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin.
    Author: Osz E, Somsák L, Szilágyi L, Kovács L, Docsa T, Tóth B, Gergely P.
    Journal: Bioorg Med Chem Lett; 1999 May 17; 9(10):1385-90. PubMed ID: 10360741.
    Abstract:
    Reaction of C-(1-bromo-1-deoxy-beta-glucopyranosyl)formamide 2 with thiocyanate ions was the key step of a short synthesis of D-glucopyanosylidene-spiro-thiohydantoin 7 which proved to be a potent inhibitor of muscle and liver glycogen phosphorylases.
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