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  • Title: Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936.
    Author: Sum PE, Petersen P.
    Journal: Bioorg Med Chem Lett; 1999 May 17; 9(10):1459-62. PubMed ID: 10360756.
    Abstract:
    A number of new glycylcyclines were synthesized for structure-activity relationship study. Many of the derivatives exhibit potent, broad spectrum antibacterial activity against both tetracycline susceptible and resistant organisms. GAR-936 (TBG-MINO) shows better activity than the previously reported DMG-MINO and DMG-DMDOT.
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