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  • Title: [Discrimination between genetic factors in attention deficit].
    Author: Lopera F, Palacio LG, Jiménez I, Villegas P, Puerta IC, Pineda D, Jiménez M, Arcos-Burgos M.
    Journal: Rev Neurol; ; 28(7):660-4. PubMed ID: 10363289.
    Abstract:
    INTRODUCTION AND OBJECTIVE: In order to elucidate the genetic and environmental components involved in the susceptibility to develop attention deficit hyperactivity disorder (ADHD), a complex segregation analysis on nuclear families (n = 53) ascertained from affected probands belonging to Medellín, in the Antioquian State, Colombia, was performed. METHODS AND RESULTS: Models of cohort effect (non-inheritance), multifactorial, recessive major gene, non-major gene component and non-transmission of major gene were rejected. Contrarily, dominant and codominant major gene models and non-multifactorial component could not be rejected. Thus, the better model fitting the data was that of the major gene (dominant/codominant). This major gene explains more than 99.99% of the ADHD phenotypic variance (value of heritability in the mixed model equal to 0.007%), which permit to assume a low aport of the environmental component to the phenotype ADHD. Gene frequency of the major gene was 3% in the general population of Antioquia and its penetrance was closed to 30%. CONCLUSION: Some cautions and aspects related to the bias of the interview and diagnosis of the parents are discussed.
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