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  • Title: Experiments on a new phosphine-peptide chelator for labelling of peptides with Tc-99m.
    Author: Santimaria M, Blok D, Feitsma RI, Mazzi U, Pauwels EK.
    Journal: Nucl Med Biol; 1999 Apr; 26(3):251-8. PubMed ID: 10363795.
    Abstract:
    A phosphine-containing ligand providing a N-[N-[3-(diphenylphosphino)propionyl]glycyl]-L-S-benzyl-cystein (PNNS) donor atomset for the chelation of 99mTc was studied in labelling experiments with a model peptide (tetragastrin, cholecystokinin-fragment). The peptide was conjugated to the ligand chelator by active ester chemistry either before or after radiolabelling. Both the chelator-conjugate and the preformed chelate approaches resulted in the same radiolabelled isomers of the ligand peptide. Sequence and reaction conditions influence yield and purity.
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