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  • Title: Effects of pituitary graft and 2-bromo-alpha-ergocryptine on mammary DNA synthesis in mice in relation to mammary tumorigenesis.
    Author: Yanai R, Nagasawa H.
    Journal: J Natl Cancer Inst; 1976 May; 56(5):1055-6. PubMed ID: 1036504.
    Abstract:
    3H-thymidine incorporation into mammary DNA as an index of mammary DNA synthesis in C3H/He virgin females was significantly higher at proestrus than at estrus and diestrus. The rise in incorporation at proestrus was completely blocked by the administration of 2-bromo-alpha-ergocryptine (Bromocriptin) 1 day before proestrus. The incorporation was maintained at a higher level than that at proestrus by pituitary grafts. The results supported the view that mammary DNA synthesis, which is stimulated by prolactin, is an important factor for mammary tumorigenesis.
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