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  • Title: Cell cycle arrest in endometrial carcinoma cells exposed to gonadotropin-releasing hormone analog.
    Author: Kim JW, Lee YS, Kim BK, Park DC, Lee JM, Kim IK, Namkoong SE.
    Journal: Gynecol Oncol; 1999 Jun; 73(3):368-71. PubMed ID: 10366462.
    Abstract:
    Gonadotropin-releasing hormone (GnRH) has been shown to have an inhibitory effect on the growth of several hormone-dependent human tumors. We have treated a human endometrial cancer cell line which expresses GnRH receptor with GnRH analog, D-Trp6-LHRH, in order to study whether there are differences in cell cycle kinetic response. Flow cytometric analysis revealed that cultured carcinoma cells showed a cell cycle arrest at the G1-S transition after treatment with 10 microM D-Trp6-LHRH for 36 h. Western blot analysis showed that the level of p16 protein was obvious following 24 h of D-Trp6-LHRH treatment. These results suggest that the mechanism by which GnRH inhibits the growth of endometrial carcinoma cells may include effects on cell cycle arrest.
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