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  • Title: Intrathecal antibiotic therapy for neonatal meningitis.
    Author: Yeung CY.
    Journal: Arch Dis Child; 1976 Sep; 51(9):686-90. PubMed ID: 1036671.
    Abstract:
    Twenty infants with neonatal meningitis were treated with systemic and lumbar intrathecal antibiotics upon initial diagnosis. Failure to sterilize the CSF in 2-3 days was associated with evidence of ventriculitis in these infants who were then treated with intraventricular antibiotics. 4 infants died, but only 2 of them may be regarded as treatment failure. It is suggested that many deaths from neonatal meningitis may be preventable by early detection and treatment of ventriculitis with intraventricular antibiotics.
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