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  • Title: [Dynamic changes of nitric oxide and biochemistry in rats with intrahepatic cholestasis].
    Author: Pei Q, Wang D, Jiang M.
    Journal: Zhonghua Gan Zang Bing Za Zhi; 1999 Mar; 7(1):44-5. PubMed ID: 10366988.
    Abstract:
    OBJECTIVE: To investigate the correlation between nitric oxide and biochemical changes of intrahepatic cholestasis. METHODS: Studies were made on endogenous NO, biochemical changes of cholestasis, liver mitochondrial function and renal excretion in a rat model at different time points after ANIT administration. RESULTS: In acute reactive phase, serum bilirubin, ALT, AKP, and bile acids significantly increased, accompanied by enhanced plasma NO and renal excretion. Liver NO increased and mitochondrial SDH activity decreased for 2-6 days after ANIT. There was a high negative correlation between liver NO and mitochondrial SDH activity (r = -0.92). CONCLUSION: These results show that higher liver NO may be an important mediator of intrahepatic cholestasis. However, plasma NO increase may play a role in rapidly decreasing serum bilirubin and restoring bile acids, ALT, and AKP to control levels by mediating enhanced renal excretion.
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