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  • Title: [Kinetics of ampicillin, oxacillin and carbenicillin after a short intravenous infusion in man].
    Author: Wirth K, Hengstmann JH, Langebartels FH, Träger S.
    Journal: Arzneimittelforschung; 1976; 26(9):1709-15. PubMed ID: 1036706.
    Abstract:
    Within 5 min 5 g of ampicillin, oxacillin and carbenicillin, respectively, were administered i.v. to patients with normal kidney function. Plasma levels of the antibiotic activity were measured up to 6 h following the injection. Urine was collected at intervals up to 8 h and the cumulative urinary excretion calculated. Furtheron, biologic half-life, volumes of distribution, total and renal clearance and area under the serum level curve have been assessed for the one- and the two-compartment model. For this model the amounts of drug in central and peripheral compartments were simulated. The statistical evaluation resulted in a highly significantly better fit when the data were analyzed according to the two-compartment model. Despite of these differences the physiological consequences of using the parameters of the one-compartment model were not significantly different.
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