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  • Title: Inhibition of ADP-induced platelet aggregation by adenosine tetraphosphate.
    Author: Harrison MJ, Brossmer R.
    Journal: Thromb Haemost; 1976 Nov 30; 36(2):388-91. PubMed ID: 1036839.
    Abstract:
    In contrast to previous reports, highly purified adenosine tetraphosphate (AP4) does not induce the aggregation of platelets but inhibits the aggregation and release reaction in platelet-rich plasma promoted by ADP. The inhibitory action of AP4 on the aggregation by ADP is compared with that of AMP and ATP. The data presented suggest a competitive manner of inhibition of the ADP-induced aggregation by AP4.
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