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  • Title: Synthesis and cytotoxicity of aminosterols: activity studies on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6).
    Author: el Kihel L, Bosch S, Dherbomez M, Roussakis C, Letourneux Y.
    Journal: Anticancer Res; 1999; 19(2A):1229-34. PubMed ID: 10368680.
    Abstract:
    Various new aminosterols were synthesized. The antiproliferative activity of these compounds (I-IV) was studied in vitro on a continuous human non small-cell bronchopulmonary carcinoma line (NSCLC-N6) at the cell cycle level. The histograms indicate cell blockage in Phase Gl (compound I-III) associated with a reduction in the number of cells phases S and G2M and appearance of cellular debris derived from cells in Phase G1.
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