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  • Title: Vasodilating effect of ethyl apovincaminate on conjunctival vessels and simultaneous observation of parameters indicating adverse effect.
    Author: Brooser G, Anda L, Domán J.
    Journal: Arzneimittelforschung; 1976; 26(10a):1975-7. PubMed ID: 1037227.
    Abstract:
    The vasodilator effect of ethyl apovincaminate (RGH-4405, Cavinton) on conjunctival vessels and its possible adverse effects have been studied in 17 patients of varying age (16-78 years) and diagnosis, as well as in healthy individuals. Intravenous 10 mg doses of the drug increased the arteriolar lumen in each case, the most markedly at 30 sec after administration of the drug, but at 90 sec effect was still significant. Before starting Cavinton, on the next day following injection and on other mornings after administration, haemoglobin, the leukocyte count, SGOT, SGPT, thymol turbidity, and blood sugar were determined. In the eight cases of juvenile hypertension urinary serum proteins were also registered after quantitative testing. The parameters investigated did not reveal any sign pointing to toxicity.
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