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  • Title: Lead and calcium transport in human erythrocyte.
    Author: Calderón-Salinas JV, Quintanar-Escorcia MA, González-Martínez MT, Hernández-Luna CE.
    Journal: Hum Exp Toxicol; 1999 May; 18(5):327-32. PubMed ID: 10372755.
    Abstract:
    In this paper we report the lead (Pb) and calcium (Ca) uptake by erythrocyte ghosts. In both cases the transport was carried out by a passive transport system with two kinetic components (Michaelis-Menten and Hill). Pb and Ca were capable of inhibiting the transport of the other metal in a non-competitive way. Under hyperpolarization, the uptakes of Ca and Pb were enhanced and the Michaelis-Menten component prevailed. Both Ca and Pb uptakes were inhibited by N-ethyl-maleimide to the same extent. These results indicate that Pb and Ca share the same permeability pathway in human erythrocytes and that this transport system is electrogenic.
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