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  • Title: Antithymocyte globulin treatment of orbital Wegener granulomatosis: a follow-up study.
    Author: Kool J, de Keizer RJ, Siegert CE.
    Journal: Am J Ophthalmol; 1999 Jun; 127(6):738-9. PubMed ID: 10372895.
    Abstract:
    PURPOSE: To describe the follow-up of patients with orbital Wegener granulomatosis after antithymocyte globulin treatment. METHODS: Patients with ocular/orbital Wegener granulomatosis refractory to standard treatment were selected for immunotherapy with rabbit antithymocyte globulin intravenously. The specific ocular/orbital symptoms were monitored in patients with a vision-threatening form of Wegener granulomatosis or a life-threatening form with ocular symptoms. RESULTS: One patient had a complete remission, two patients had remissions but still needed additional treatment, and one patient remained refractory. CONCLUSIONS: In selected patients, antithymocyte globulin immunotherapy may present an alternative when vision or life is threatened by orbital Wegener granulomatosis.
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