These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Paraoxonase 1 mutations in a Turkish population.
    Author: Aynacioglu AS, Cascorbi I, Mrozikiewicz PM, Nacak M, Tapanyigit EE, Roots I.
    Journal: Toxicol Appl Pharmacol; 1999 Jun 15; 157(3):174-7. PubMed ID: 10373401.
    Abstract:
    Human serum paraoxonase 1 (PON1) catalyzes the hydrolysis of certain organophosphate pesticides and nerve gases and so may alter significantly an individual's susceptibility to the toxicity of these chemicals. Moreover, PON1 hydrolyzes lipid peroxides complexed to low density lipoproteins (LDL) and therefore it was suggested that PON1 may be one of the genes that is involved in the pathogenesis of cardiovascular diseases. Its activity shows interindividual and interethnic variability. At least two mutation sites, namely Gln192Arg (Q/R) and Leu55Met (L/M) were reported responsible for the variations in enzyme activity. The aim of the present study was to determine the frequency of these mutations in Turks and compare the results with other European and Oriental populations. A total of 381 unrelated Turkish individuals were genotyped for Gln192Arg and Leu55Met polymorphisms by PCR-RFLP using AlwI and NlaIII, respectively. Genotype distribution was QQ = 0.49, QR = 0.40, RR = 0.11, and LL = 0.52, LM = 0.39, MM = 0.09. Thus frequencies of high activity alleles R (Arg) and L (Leu) were found as 0.31 and 0.72, respectively. The frequency of these alleles was slightly higher in Turkish subjects than other Caucasian populations but much lower compared to Oriental populations.
    [Abstract] [Full Text] [Related] [New Search]