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  • Title: [Optic neuritis, brain stem syndromes and myelitis: rapid conversion to multiple sclerosis].
    Author: Tintoré M, Rovira A, Hernández D, Río J, Marzo ME, Montalban X.
    Journal: Med Clin (Barc); 1999 May 22; 112(18):693-4. PubMed ID: 10374200.
    Abstract:
    BACKGROUND: To establish the early risk of multiple sclerosis (MS) following isolated demyelinating syndromes. PATIENTS AND METHOD: 36 patients with optic neuritis, 24 with brainstem syndromes, 27 with spinal cord syndromes and 8 patients with a poliregional syndrome were included in a prospective protocol: including clinical data, immunological determinations, oligoclonal bands, visual, somestesic and brainstem evoked potentials and a magnetic resonance imaging (MRI) study. RESULTS: MRI showed the presence of signal abnormalities in 70% of the patients. The conversion rate (CR) was 18.5%. In patients with a normal MRI, CR was 4% compared to 26% in patients with an abnormal MRI (p = 0.05). CONCLUSIONS: The early conversion rate to MS is significantly increased when MRI is abnormal.
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