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  • Title: [The effects of IFN-gamma on the antitumor abilities of immunocytes and chemotherapeutic agents].
    Author: Gu Q, Zhu Z, Yin H.
    Journal: Zhonghua Wai Ke Za Zhi; 1997 Feb; 35(2):89-91. PubMed ID: 10374484.
    Abstract:
    We studied the effects of IFN-gamma in immunotherapy and chemoimmunotherapy. The effects of IFN-gamma on TIL and LAK cytotoxicities on K562 tumor cell line and MKN45 gastric cancer tumor were observed. The antitumor effects of 5 chemotherapeutic agents with or without IFN-gamma on SGC7901 gastric cancer cell line were evaluated. The results showed that: (1) IFN-gamma obviously enhanced the cytotoxicities of TIL and LAK on 2 cell line: (2) IFN-gamma also increased the antitumor abilities of 5 agents on SGC7901 cell line. The study suggested that IFN-gamma is useful in immunotherapy and chemoimmunotherapy as an important immunomodulating agent.
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