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  • Title: [Portal-systemic shunting and hemodynamics of prehepatic portal hypertensive rat models].
    Author: Zhou YB, Leng X, Qi G.
    Journal: Zhonghua Wai Ke Za Zhi; 1997 Apr; 35(4):244-7. PubMed ID: 10374550.
    Abstract:
    Hemodynamics and relationship between portal-systemic shunting and portal pressure were measured by radioactive microsphere techniques in 31 rats after various degree portal vein constriction. Prominent hyperdynamic state was present in prehepatic portal hypertensive rats models. Both cardiac output and index were increased, the mean arterial pressure and pripheral resistance were reduced significantly. The total splanchnic blood flow was increased but splanchnic resistance reduced remarkably. Portal-systemic shunting flow was higher. There was a significant positive correlation between them, Y = 26.14 + 5.32X (r = 0.76, P < 0.001). For this reason, elevated systemic and portal venous flow provided main impetus for maintaining portal hypertension.
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