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  • Title: Efficient export of the glucose transporter Hxt1p from the endoplasmic reticulum requires Gsf2p.
    Author: Sherwood PW, Carlson M.
    Journal: Proc Natl Acad Sci U S A; 1999 Jun 22; 96(13):7415-20. PubMed ID: 10377429.
    Abstract:
    Mutations in the GSF2 gene cause glucose starvation phenotypes in Saccharomyces cerevisiae. We have isolated the HXT1 gene, which encodes a low-affinity, high-capacity glucose transporter, as a multicopy suppressor of a gsf2 mutation. We show that gsf2 mutants accumulate Hxt1p in the endoplasmic reticulum (ER) and that Gsf2p is a 46-kDa integral membrane protein localized to the ER. gsf2 mutants also display a galactose growth defect and abnormal localization of the galactose transporter Gal2p but are not defective in function or localization of the high-affinity glucose transporter Hxt2p. These findings suggest that Gsf2p functions in the ER to promote the secretion of certain hexose transporters.
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