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  • Title: [Maternal-fetal transmission of HCV. Role of HIV as a risk factor].
    Author: Catalano D, Pollio F, Ercolano S, Ascione L, Desantis B, Russo C.
    Journal: Minerva Ginecol; 1999 Apr; 51(4):117-9. PubMed ID: 10379146.
    Abstract:
    BACKGROUND: The aim of this study is to determine the rate of vertical transmission of hepatitis C and to analyse the concomitant infection by HIV as a risk factor. METHODS: We have studied the perinatal transmission of HCV in 22 pregnancies: 14 in women HCV+/HIV-, 8 in women HCV+/HIV+. We have performed the following tests on sera: test RIBA II to search for Ab anti-HCV, alanine transaminase (ALT) evaluation and HCV-RNA research by PCR. These tests were performed on sera from infants at birth and, then, during one year every three months. RESULTS: Within one year Ab anti-HCV disappeared in 20 of 22 pregnancies: two infants positive by Ab anti-HCV were born to HIV+ mothers and they were the only two who showed abnormal ALT values and detectable levels of HCV-RNA. Finally 10 of 14 infants born to HCV+/HIV- mothers were breast-fed and none was infected. CONCLUSIONS: We conclude that HCV mother-to-child transmission is an uncommon event, breast-milking is safety, and the concomitant infection by HIV could represent a risk factor for vertical transmission of hepatitis C.
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