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  • Title: Human immune response to a peptide mimic of Neisseria meningitidis serogroup C in hu-PBMC-SCID mice.
    Author: Hutchins WA, Kieber-Emmons T, Carlone GM, Westerink MA.
    Journal: Hybridoma; 1999 Apr; 18(2):121-9. PubMed ID: 10380011.
    Abstract:
    An anti-idiotype-based peptide mimic vaccine for Neisseria meningitidis serogroup C polysaccharide (MCPS) has been developed and shown to induce a response in mice that is specific, functional, and T-dependent. In this study, the immunogenicity of the MCPS peptide mimic vaccine preparation, as a potential vaccine for use in humans, is shown using the hu-PBMC-SCID mouse model. The human antibody response to the MCPS peptide mimic vaccine is specific and functional as shown by inhibition enzyme-linked immunoadsorbent assay (ELISA) and bactericidal assay. These data support the usefulness of the peptide mimic vaccine strategy for humans.
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